Publications

Publication Acknowledgement

All publications of research involving the HTSC should be reported to HTSC management and should include an acknowledgement or authorship as discussed prior to publication.

If research on a cancer project involving the HTSC results in publication, please acknowledge this support by including the following in your publications(s):

We thank the Alvin J. Siteman Cancer Center at Washington University School of Medicine and Barnes-Jewish Hospital in St. Louis, MO., for use of the High-Throughput Screening Core, which provided________________service. The Siteman Cancer is supported in part by an NCI Cancer Center Support Grant #P30 CA91842.

Representative Publications

33. Han Z, Harris PKW, Jones DE, Chugani R, Kim T, Agarwal M, Shen W, Wildman SA, Janetka JW. Inhibitors of HGFA, Matriptase and Hepsin Serine Proteases: A Non-Kinase Strategy to Block Cell Signaling in Cancer. ACS Med. Chem. Lett. 2014.

32. Holmes BB, Diamond MI (2014) Prion-like Properties of Tau Protein: The Importance of Extracellular Tau as a Therapeutic Target. J. Biol. Chem. 2014;289:19855-19861

31. Nickless A, Jackson E, Marasa J, Nugent P, Mercer RW, Piwnica-Worms D, You ZS (2014) Intracellular calcium regulates nonsense-mediated mRNA decay. Nat. Med. 2014;10:961-966.

30. Elhammali A, Ippolito J, Collins L, Marasa J, Piwnica-Worms D (2013) A High-Throughput Fluorimetric Assay for 2-hydroxyglutarate Identifies Zaprinast as a Glutaminase Inhibitor. Cancer Discov. 2014;4:828-839.

29. Sengupta R, Marassa J, Piwnica-Worms D, Rubin J (2013) Gbm Perivascular Niche Disrupting Agents Identified Through A Novel High Throughput Compound Library Screen. Neuro-Oncology 2013;15:57.

28. Boyer AP, Collier TS, Vidavsky I, Bose R (2013) Quantitative Proteomics with siRNA Screening Identifies Novel Mechanisms of Trastuzumab Resistance in HER2 Amplified Breast Cancers. Mol Cell Proteomics. 2013;12:180-93.

27. Holmes B, DeVos S, Kfoury N, Li M, Jacks R, Yanamandra K, Ouidja M, Brodsky F, Marasa J, Bagchi D, Kotzbauer P, Miller T, Papy-Garcia D, Diamond M (2013) Heparan Sulfate Proteoglycans Mediate Internalization and Propagation of Specific Proteopathic Seeds. PNAS 2013;110:E3138-47.

26. Zheng Z, Li A, Holmes BB, Marasa JC, Diamond MI (2013) An N-terminal Nuclear Export Signal Regulates Trafficking and Aggregation of Huntingtin (Htt) Protein Exon 1. J Biol Chem. 2013;288:6063-71

25. Johnson JR, Kocher B, Barnett EM, Marasa J, Piwnica-Worms D. Caspase-Activated Cell-Penetrating Peptides Reveal Temporal Coupling Between Endosomal Release and Apoptosis in an RGC-5 Cell Model. Bioconjug Chem. 2012;23:1783-93.

24. Lee S, Stewart S, Nagtegaal I, Luo J, Wu Y, Colditz G, Medina D, Allred DC. Differentially expressed genes regulating the progression of ductal carcinoma in situ to invasive breast cancer. Cancer Res. 201;72:4574-86

23. Moss BL, Elhammali A, Fowlkes T, Gross S, Vinjamoori A, Contag CH, Piwnica-Worms D. Interrogation of IκBα:NF-κB (inhibitor of nuclear factor κB α:nuclear factor κB) negative feedback loop dynamics: from single cells to live animals in vivo. J Biol Chem 2012;287:31359-31370

22. Flentie K, Kocher B, Gammon ST, Novack DV, McKinney JS, Piwnica-Worms D. A bioluminescent transposon reporter-trap identifies tumor-specific microenvironment-induced promoters in Salmonella for conditional bacterial-based tumor therapy. Cancer Discovery 2012; 2:624–637.

21. Chiappinelli KB, Haynes BC, Brent MR, Goodfellow PJ. Reduced DICER1 elicits an interferon response in endometrial cancer cells. Mol Cancer Res 2012;10:316-325.

20. Goetzinger KR, Cahill AG, Kemna J, Odibo L, Macones GA, Odibo AO. First-trimester prediction of preterm birth using ADAM12, PAPP-A, uterine artery Doppler, and maternal characteristics. Prenat Diagn. 2012;31:1-6.

19. Zhang K, Rodriguez-Aznar E, Yabuta N, Owen RJ, Mingot JM, Nojima H, Nieto MA, Longmore GD. Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation. EMBO J, 2012;31:29 – 43.

18. Chen DY, Lee Y, Van Tine BA, Searleman AC, Westergard TD, Liu H, Tu H-C, Takeda S, Dong Y, Piwnica-Worms D, Oh KJ, Korsmeyer SJ, Hermone A, Gussio R, Shoemaker RH, Cheng EH-Y, Hsieh JJ-D. A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth. Cancer Res 2012; 72:736-746.

17. Fuentealba RA, Marasa J, Diamond MI, Piwnica-Worms D, Weihl CC. An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitors. Hum. Mol. Genet. 2012;21:664-680.

16. Chinault SL, Prior JL, Kaltenbronn KM, Penly A, Weilbaecher KN, Piwnica-Worms D, Blumer KJ. Breast cancer cell targeting by prenylation inhibitors elucidated in living animals with a bioluminescence reporter. Clin Cancer Res 2012; 18:4136-4144.

15. Ilagan MX, Lim S, Fulbright M, Piwnica-Worms D, Kopan R. Real-time imaging of notch activation with a luciferase complementation-based reporter. Sci Signal. 2011;4:rs7.

14. Srikanta D, Yang M, Williams M, Doering TL. A sensitive high-throughput assay for evaluating host-pathogen interactions in Cryptococcus neoformans infection. PLoS One. 2011;6:e22773.

13. Gerdts J, Sasaki Y, Vohra B, Marasa J, Milbrandt J. Image-based screening identifies novel roles for IkappaB kinase and glycogen synthase kinase 3 in axonal degeneration. J Biol Chem. 2011;286:28011-8.

12. Luo X, Ruhland MK, Pazolli E, Lind AC, Stewart SA. Osteopontin stimulates preneoplastic cellular proliferation through activation of the MAPK pathway. Mol Cancer Res. 2011;9:1018-29.

11. Blaxall BC, Muslin AJ. Cardiovascular Therapeutic Discovery. J. Cardio. Trans. Res. 2010;3 SI: 429.

10. Muslin AJ. Phenotypic High-Throughput Screening in Atherosclerosis Research: Focus on Macrophages. J. Cardio. Trans. Res. 2010;3 SI: 438-453.

9. Banerjee S, Byrd JN, Gianino SM, Harpstrite SE, Rodriguez FJ, Tuskan RG, Reilly KM, Piwnica-Worms DR, Gutmann DH. The neurofibromatosis type 1 tumor suppressor controls cell growth by regulating signal transducer and activator of transcription-3 activity in vitro and in vivo. Cancer Res. 2010;701356-66.

8. Honaker Y, Piwnica-Worms H. Casein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction. Oncogene. 2010;29:3324-34.

7. Saenz JB, Li J, Haslam DB. The MAP kinase-activated protein kinase 2 (MK2) contributes to the Shiga toxin-induced inflammatory response. Cell Microbiol. 2010;12:516-29.

6. Kuhlmann FM, Nolan B, Gohara B, Hsu F-F, Turk J, Beverly SM. Novel Lipid Biosynthetic Pathways In Leishmania Chemotherapeutics. Am. J. Trop. Med. Hygiene 2009; 81:36.

5. Etzion Y, Hackett A, Proctor BA, Ren J, Nolan B, Ellenberger T, Muslin AJ. An Unbiased Chemical Biology Screen Identifies Agents That Modulate Uptake of Oxidized LDL by Macrophages. Circ. Res. 2009;105:148-157.

4. Naik S, Dothager RS, Marasa J, Lewis CL, Piwnica-Worms D. Vascular Endothelial Growth Factor Receptor-1 Is Synthetic Lethal to Aberrant {beta}-Catenin Activation in Colon Cancer. Clin Cancer Res. 2009;15:7529-7537.

3. Maxwell D, Chang Q, Zhang X, Barnett EM, Piwnica-Worms D. An improved cell-penetrating, caspase-activatable, near-infrared fluorescent peptide for apoptosis imaging. Bioconjug Chem. 2009;20:702-9.

2. Pandey N, Strider J, Nolan WC, Yan SX, Galvin JE. Curcumin inhibits aggregation of a-synuclein. Acta Nueropathol. 2008; 115:479-489.

1. Ellenberger T, Cotner-Gohara E, Oberman R, Kim I-K, Nolan W, Tomkinson A, Scharer OD. Structure-based Inhibitors of DNA Repair. FASEB J. 2008;22:526.

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